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Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit⁺ cells through the activation of an inflammatory hypoxia-dependent reparative response.

ABSTRACT: The regenerative effects of cardiac ckit⁺ stem cells (ckit⁺CSCs) in acute myocardial infarction (MI) have been studied extensively, but how these cells exert a protective effect on cardiomyocytes is not well known. Growing evidences suggest that in adult stem cells injury triggers inflammatory signaling pathways which control tissue repair and regeneration. Aim of the present study was to determine the mechanisms underlying the cardioprotective effects of ckit⁺CSCs following transplantation in a murine model of MI. Following isolation and in vitro expansion, cardiac ckit⁺CSCs were subjected to normoxic and hypoxic conditions and assessed at different time points. These cells adapted to hypoxia as showed by the activation of HIF-1α and the

SUBMITTER: Puddighinu G

PROVIDER: S-EPMC5787525 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit⁺ cells through the activation of an inflammatory hypoxia-dependent reparative response.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit+ cells through the activation of an inflammatory hypoxia-dependent reparative response.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit⁺ cells through the activation of an inflammatory hypoxia-dependent reparative response.