Stress Resilience of Spermatozoa and Blood Mononuclear Cells without Prion Protein.

ABSTRACT: The cellular prion protein PrP^C is highly expressed in neurons, but also present in non-neuronal tissues, including the testicles and spermatozoa. Most immune cells and their bone marrow precursors also express PrP^C. Clearly, this protein operates in highly diverse cellular contexts. Investigations into putative stress-protective roles for PrP^C have resulted in an array of functions, such as inhibition of apoptosis, stimulation of anti-oxidant enzymes, scavenging roles, and a role in nuclear DNA repair. We have studied stress resilience of spermatozoa and peripheral blood mononuclear cells (PBMCs) derived from non-transgenic goats that lack PrP^C (PRNP^Ter/Ter) compared with cells from normal (PRNP^+/+) goats. Spe

SUBMITTER: Reiten MR 

PROVIDER: S-EPMC5787566 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature