Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites.

ABSTRACT: AIM:To assess the relationship between the presence of toll-like receptor 4 (TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS:We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus (HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma (beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299G and/or T399I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during f

SUBMITTER: Alvarado-Tapias E 

PROVIDER: S-EPMC5787676 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature