Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis.

ABSTRACT: AIM:To identify the key epigenetically modulated genes and pathways in HCC by performing an integrative meta-analysis of all major, well-annotated and publicly available methylation datasets using tools of network analysis. METHODS:PubMed and Gene Expression Omnibus were searched for genome-wide DNA methylation datasets. Patient clinical and demographic characteristics were obtained. DNA methylation data were integrated using the Ingenuity Pathway Analysis, a software package for visualizing and analyzing biological networks. Pathway enrichment analysis was performed using IPA, which also provides literature-driven and computationally-predicted annotations for significant association of genes to curated molecular pathways. RESULTS:From an initial 928 potential abstracts, we identified and

SUBMITTER: Bhat V 

PROVIDER: S-EPMC5787679 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature