Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience.

ABSTRACT: AIM:To evaluate the efficacy of direct-acting antivirals (DAAs) in Kanto Rosai Hospital. METHODS:All patients with hepatitis C virus (HCV) who underwent DAA prescription were enrolled in this study. The present study was a single center retrospective analysis using patients infected with HCV genotype 1 or 2. Resistance analysis was performed by using direct sequencing and cycleave PCR in genotype 1 patients treated with interferon (IFN)-free DAA. The primary endpoint was sustained virologic response at 12 wk after therapy (SVR12). RESULTS:A total of 117 patients participated in the study, including 135 with genotype 1 and 42 with genotype 2. Of the 135 patients with genotype 1, 16 received protease inhibitor + IFN + ribavirin and all achieved SVR. Of the 119 patients who received IFN-free

SUBMITTER: Kaneko R 

PROVIDER: S-EPMC5787689 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature