Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins.

ABSTRACT: Immunocytokines are fusion proteins that combine the specific antigen binding capacities of an antibody or derivative thereof and the potent bioactivity of a cytokine partner. These novel biopharmaceuticals have been directed to various targets of oncological as well as non-oncological origin and a handful of promising constructs are currently advancing in the clinical trial pipeline. Several factors such as the choice of a disease specific antigen, the antibody format and the modulatory nature of the payload are crucial, not only for therapeutic efficacy and safety but also for the commercial success of such a product. In this review, we provide an overview of the basic principles and obstacles in immunocytokine design with a specific focus on single chain antibody fragment-based construc

SUBMITTER: Fercher C 

PROVIDER: S-EPMC5788148 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature