β-Thromboglobulin and incident cardiovascular disease risk: The Atherosclerosis Risk in Communities study.

ABSTRACT:

Introduction

Although it has been suggested that increased concentrations of activated platelet biomarkers are associated with increased risk of incident cardiovascular disease (CVD) in the general population, evidence for this association is still controversial. Thus, we tested the hypothesis that activated platelets, measured by higher concentrations of β-thromboglobulin, are associated with increased risk of incident CVD (coronary heart disease, heart failure ischemic stroke, and atrial fibrillation).

Materials and methods

We prospectively followed a cohort random sample of the Atherosclerosis Risk in Communities (ARIC) cohort, aged 45-64years, and free of CVD at baseline who had previous measurements of plasma β-thromboglobulin. We identified incident CVD from 1987 throu

SUBMITTER: Kubota Y 

PROVIDER: S-EPMC5788197 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature