Ontology highlight
ABSTRACT:
SUBMITTER: Perdomo S
PROVIDER: S-EPMC5788352 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
PloS one 20180129 1
We investigated how somatic changes in HNSCC interact with environmental and host risk factors and whether they influence the risk of HNSCC occurrence and outcome. 180-paired samples diagnosed as HNSCC in two high incidence regions of Europe and South America underwent targeted sequencing (14 genes) and evaluation of copy number alterations (SCNAs). TP53, PIK3CA, NOTCH1, TP63 and CDKN2A were the most frequently mutated genes. Cases were characterized by a low copy number burden with recurrent fo ...[more]