Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling.

ABSTRACT: Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases. Here, we perform RNA sequencing on blood samples collected from children evaluated in an emergency room setting with diarrheal disease where the pathogen(s) present are known. We determine host response gene signatures specific to Salmonella, Shigella and rotavirus, but not

SUBMITTER: DeBerg HA 

PROVIDER: S-EPMC5788382 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature