Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

ABSTRACT: Acute myeloid leukemia (AML) is a blood cancer that is caused by a disorder of the process that normally generates neutrophils. Function and dysfunction of neutrophils are key to physiologic defense against pathogens as well as pathologies including autoimmunity and cancer. A major mechanism through which neutrophils contribute to health and disease is oxidative burst, which involves rapid release of reactive oxygen species (ROS) generated by a chemical reaction network catalyzed by enzymes including NADPH oxidase and myeloperoxidase (MPO). Due to the involvement of neutrophil-derived reactive oxygen species in many diseases and importance of NADPH oxidase and MPO-mediated reactions in progression and treatment of myeloid leukemia, monitoring this process and modulating it by pharmacologic

SUBMITTER: Rossetto Burgos RC 

PROVIDER: S-EPMC5788618 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature