Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach.

ABSTRACT: It has recently been suggested that pro-tumorigenic host-mediated processes induced in response to chemotherapy counteract the anti-tumor activity of therapy, and thereby decrease net therapeutic outcome. Here we use experimental data to formulate a mathematical model describing the host response to different doses of paclitaxel (PTX) chemotherapy as well as the duration of the response. Three previously described host-mediated effects are used as readouts for the host response to therapy. These include the levels of circulating endothelial progenitor cells in peripheral blood and the effect of plasma derived from PTX-treated mice on migratory and invasive properties of tumor cells in vitro. A first set of mathematical models, based on basic principles of pharmacokinetics/pharmacody

SUBMITTER: Benguigui M 

PROVIDER: S-EPMC5788661 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature