Accumulation of Antigen-Driven Lymphoproliferations in Complement Receptor 2/CD21^-/low B Cells From Patients With Sjogren's Syndrome.

ABSTRACT:

Objective

Patients with Sjögren's syndrome (SS) are prone to develop malignant lymphomas, and a correlation has been established between the lymphoproliferations occurring in these disorders and the presence in patients' blood of an unusual B cell population that down-regulates complement receptor 2/CD21. This study was undertaken to identify the B cell compartment from which these lymphoproliferations emerge and determine the mechanisms that promote clonal B cell expansion in patients with SS.

Methods

The reactivity of antibodies expressed by CD19+CD10-CD27-IgM+CD21^-/low cells isolated from the blood of patients with SS was tested using a polymerase chain reaction-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by sin

SUBMITTER: Glauzy S 

PROVIDER: S-EPMC5788702 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature