Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis.

ABSTRACT:

Objective

Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary tract infections. HLA-B27 positivity is considered a risk factor, although it is not necessarily predictive of disease incidence. Among nongenetic factors, the intestinal microbiome may play a role in disease susceptibility. The objective of this study was to characterize the gut microbiota and host gene interactions in ReA and postinfectious spondyloarthritis.

Methods

Adult subjects with peripheral spondyloarthritis and control subjects with preceding infections who did not develop arthritis were prospectively recruited from a geographic region with a high prevalence of ReA. Clinical variables, HLA status, and 16S ribosomal RNA gene sequencing of in

SUBMITTER: Manasson J 

PROVIDER: S-EPMC5788722 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature