Poor recovery from a pulmonary exacerbation does not lead to accelerated FEV₁ decline.

ABSTRACT:

Background

Patients with CF treated for pulmonary exacerbations (PEx) may experience faster subsequent declines in FEV₁. Additionally, incomplete recovery to baseline FEV₁ occurs frequently following PEx treatment. Whether accelerated declines in FEV₁ are preceded by poor PEx recovery has not been studied.

Methods

Using 2004 to 2011 CF Foundation Patient Registry data, we randomly selected one PEx among patients ≥6years of age with no organ transplantations, ≥12months of data before and after the PEx, and ≥1 FEV₁ recorded within the 6months before and 3months after the PEx. We defined poor PEx recovery as the best FEV₁ in the 3months after the PEx <90% of the best FEV₁ in the 6months before the PEx. We calcula

SUBMITTER: Sanders DB 

PROVIDER: S-EPMC5788732 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature