Bolusing frequency and amount impacts glucose control during hybrid closed-loop.

ABSTRACT:

Aim

To compare bolus insulin delivery patterns during closed-loop home studies in adults with suboptimally [HbA_1c 58-86 mmol/mol (7.5%-10%)] and well-controlled [58 mmol/mol (< 7.5%)] Type 1 diabetes.

Methods

Retrospective analysis of daytime and night-time insulin delivery during home use of closed-loop over 4 weeks. Daytime and night-time controller effort, defined as amount of insulin delivered by closed-loop relative to usual basal insulin delivery, and daytime bolus effort, defined as total bolus insulin delivery relative to total daytime insulin delivery were compared between both cohorts. Correlation analysis was performed between individual bolus behaviour (bolus effort and frequency) and daytime controller efforts, and proportion of time spent within and

SUBMITTER: Bally L 

PROVIDER: S-EPMC5788742 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature