Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.

ABSTRACT: Serotonin is a monoamine neurotransmitter that signals through a wide array of receptors (5-HT_1-7) many of which are also involved in immune processes. Dendritic cells (DCs) are crucial players in immune defense by bridging innate and adaptive immune responses via their vast repertoire of pattern recognition receptors and antigen-presenting capability. Although serotonin is known to influence immunity at many levels, cell type-specific expression and function of its receptors remains poorly understood. Here we aimed to study 5-HT_1-7 expression and function in CD1a^- and CD1a⁺ human monocyte-derived DCs (moDCs). We found that the 5-HT_2B receptor-subtype is solely expressed by the inflammatory CD1a⁺ moDC subset. Specific 5-HT

SUBMITTER: Szabo A 

PROVIDER: S-EPMC5788853 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature