Core-shell magnetoelectric nanorobot - A remotely controlled probe for targeted cell manipulation.

ABSTRACT: We have developed a remotely controlled dynamic process of manipulating targeted biological live cells using fabricated core-shell nanocomposites, which comprises of single crystalline ferromagnetic cores (CoFe₂O₄) coated with crystalline ferroelectric thin film shells (BaTiO₃). We demonstrate them as a unique family of inorganic magnetoelectric nanorobots (MENRs), controlled remotely by applied a.c. or d.c. magnetic fields, to perform cell targeting, permeation, and transport. Under a.c. magnetic field excitation (50 Oe, 60 Hz), the MENR acts as a localized electric periodic pulse generator and can permeate a series of misaligned cells, while aligning them to an equipotential mono-array by inducing inter-cellular signaling. Under a.c. magnetic field (40 Oe

SUBMITTER: Betal S 

PROVIDER: S-EPMC5788862 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature