Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

ABSTRACT: A complex network of interactions exists between the immune, the olfactory, and the central nervous system (CNS). Inhalation of different fragrances can affect immunological reactions in response to an antigen but also may have effects on the CNS and cognitive activity. We performed an exploratory study of the immunomodulatory ability of a series of compounds representing each of the 10 odor categories or clusters described previously. We evaluated the impact of each particular odor on the immune response after immunization with the model antigen ovalbumin in combination with the TLR3 agonist poly I:C. We found that some odors behave as immunostimulatory agents, whereas others might be considered as potential immunosuppressant odors. Interestingly, the immunomodulatory capacity was, in som

SUBMITTER: Lasarte-Cia A 

PROVIDER: S-EPMC5788902 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature