PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics.

ABSTRACT: Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to low oxygen conditions. Especially for space exploration scenarios, hypoxic conditions - together with reduced gravity - represent two foreseen living conditions when planning manned long-duration space missions or planetary habitats. The PlanHab study investigated microgravity through inactivity in bed rest and normobaric hypoxia to examine their independent or combined effect on adenosine and its kinetics. Healthy male subjects (n = 14) completed three 21-day interventions: hypoxic bed rest (HBR); hypox

SUBMITTER: Strewe C 

PROVIDER: S-EPMC5788919 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature