Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen.

ABSTRACT: Robustness is a key system-level property of living organisms to maintain their functions while tolerating perturbations. We investigate here how a regulatory network controlling multiple virulence factors impacts phenotypic robustness of a bacterial plant pathogen. We reconstruct a cell-scale model of Ralstonia solanacearum connecting a genome-scale metabolic network, a virulence macromolecule network, and a virulence regulatory network, which includes 63 regulatory components. We develop in silico methods to quantify phenotypic robustness under a broad set of conditions in high-throughput simulation analyses. This approach reveals that the virulence regulatory network exerts a control of the primary metabolism to promote robustness upon infection. The virulence regulatory network plugs i

SUBMITTER: Peyraud R 

PROVIDER: S-EPMC5788922 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature