Actin Cytoskeleton Affects Schwann Cell Migration and Peripheral Nerve Regeneration.

ABSTRACT: Actin cytoskeleton regulates many essential biological functions, including cellular development, shape, polarity, and motility. The organization of actin cytoskeleton has also been associated with numerous physiological and pathological conditions, for instance, the elongation of axonal growth cone during peripheral nerve regeneration. However, the spatio-temporal expression patterns of actin cytoskeleton-related genes and the specific roles of actin cytoskeleton following peripheral nerve injury have not been fully revealed. To address this question, we made rat sciatic nerve crush surgery, collected injured sciatic nerve stumps, analyzed RNA deep sequencing outcomes, and specifically studied two significantly involved canonical pathways that were related with actin, actin cytoskeleton s

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5788963 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature