A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy.

ABSTRACT: Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy sys

SUBMITTER: Desroches J 

PROVIDER: S-EPMC5788981 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature