Disrupted brain network topology in chronic insomnia disorder: A resting-state fMRI study.

ABSTRACT: This study investigated the topological characteristics of brain functional networks in chronic insomnia disorder (CID) patients. The resting-state functional magnetic resonance imaging and graph theory analysis method were applied to investigate the brain functional connectome patterns among 45 CID patients and 32 healthy controls. The brain functional connectome was constructed by thresholding partial correlation matrices of 90 brain regions from an automated anatomical labeling atlas. The topologic properties of brain functional connectomes at both global and nodal levels were tested. The CID patients had decreased number of module (p = .014) and hierarchy (p = .038), and increased assortativity (p = .035). Furthermore, some brain regions located in the default mode

SUBMITTER: Li Z 

PROVIDER: S-EPMC5789127 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature