Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes.

ABSTRACT: Chromosomal translocations drive the development of many hematological and some solid cancers. Several factors have been identified to explain the non-random occurrence of translocation breakpoints in the genome. These include chromatin density, gene density and CCCTC-binding factor (CTCF)/cohesin binding site density. However, such factors are at least partially interdependent. Using 13,844 and 1563 karyotypes from human blood and solid cancers, respectively, our multiple regression analysis only identified chromatin density as the primary statistically significant predictor. Specifically, translocation breakpoints preferentially occur in open chromatin. Also, blood and solid tumors show markedly distinct translocation signatures. Strikingly, translocation breakpoints occur significantly

SUBMITTER: Lin CY 

PROVIDER: S-EPMC5789363 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature