Precision Epitaxy for Aqueous 1D and 2D Poly(ε-caprolactone) Assemblies.

ABSTRACT: The fabrication of monodisperse nanostructures of highly controlled size and morphology with spatially distinct functional regions is a current area of high interest in materials science. Achieving this control directly in a biologically relevant solvent, without affecting cell viability, opens the door to a wide range of biomedical applications, yet this remains a significant challenge. Herein, we report the preparation of biocompatible and biodegradable poly(ε-caprolactone) 1D (cylindrical) and 2D (platelet) micelles in water and alcoholic solvents via crystallization-driven self-assembly. Using epitaxial growth in an alcoholic solvent, we show exquisite control over the dimensions and dispersity of these nanostructures, allowing access to uniform morphologies and predictable dimensions

SUBMITTER: Arno MC 

PROVIDER: S-EPMC5789388 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature