Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.

ABSTRACT: Iron-restricted human anemias are associated with the acquisition of marrow resistance to the hematopoietic cytokine erythropoietin (Epo). Regulation of Epo responsiveness by iron availability serves as the basis for intravenous iron therapy in anemias of chronic disease. Epo engagement of its receptor normally promotes survival, proliferation, and differentiation of erythroid progenitors. However, Epo resistance caused by iron restriction selectively impairs proliferation and differentiation while preserving viability. Our results reveal that iron restriction limits surface display of Epo receptor in primary progenitors and that mice with enforced surface retention of the receptor fail to develop anemia with iron deprivation. A mechanistic pathway is identified in which erythroid iron res

SUBMITTER: Khalil S 

PROVIDER: S-EPMC5789406 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature