Cardiac macrophages promote diastolic dysfunction.

ABSTRACT: Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a hallmark of cardiac aging and heart failure with preserved ejection fraction, remain unclear. Here we show that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age. A higher murine myocardial macrophage density results from monocyte recruitment and increased hematopoiesis in bone marrow and spleen. In humans, we observed a parallel constellation of hematopoietic activation: circulating myeloid cells are more frequent, and splenic ¹⁸F-FDG PET/CT imaging signal correlates with echocardiographic indices of diastolic dysfu

SUBMITTER: Hulsmans M 

PROVIDER: S-EPMC5789416 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature