Ontogeny of human mucosal-associated invariant T cells and related T cell subsets.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2⁺ CD161^highCD4^- T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2⁺ CD161^high T cell and related subset levels in infancy and after cord blood transplantation. We show that Vα7.2⁺ and Vα7.2^- CD161^high T cells are generated early during gestation and likely share a common prenatal developmental program. Among cord blood Vα7.2⁺ CD161^high T cells, the minority recognizing MR1:5-OP-RU display a TRAV/TRBV repertoire very similar to adult MAIT cells. Within a

SUBMITTER: Ben Youssef G 

PROVIDER: S-EPMC5789419 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature