Effect of intravenous lidocaine on the incidence of postextubation laryngospasm: A double-blind, placebo-controlled randomized trial.

ABSTRACT:

Objectives

The study aimed to test the effect of intraoperative intravenous (IV) lidocaine on the incidence of postextubation laryngospasm in adult patients.

Methods

The prospective randomized clinical trial was conducted at tertiary care hospital in Riyadh, between January and December 2012. Seventy-two patients undergoing laparoscopic cholecystectomy were randomly assigned to receive either placebo (n = 36) or IV lidocaine (n = 36), 1 mg/kg bolus after desflurane was discontinued. Laryngospasm was graded from 0 to 3 based on the absence or presence of signs and the severity of postextubation laryngospasm.

Results

The study was terminated early by the data monitoring committee because of safety concerns due to an increased incidence of postextubation la

SUBMITTER: Aljonaieh KI 

PROVIDER: S-EPMC5789503 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature