Host genetic variation and its microbiome interactions within the Human Microbiome Project.

ABSTRACT:

Background

Despite the increasing recognition that microbial communities within the human body are linked to health, we have an incomplete understanding of the environmental and molecular interactions that shape the composition of these communities. Although host genetic factors play a role in these interactions, these factors have remained relatively unexplored given the requirement for large population-based cohorts in which both genotyping and microbiome characterization have been performed.

Methods

We performed whole-genome sequencing of 298 donors from the Human Microbiome Project (HMP) healthy cohort study to accompany existing deep characterization of their microbiomes at various body sites. This analysis yielded an average sequencing depth of 32x, with which we ident

SUBMITTER: Kolde R 

PROVIDER: S-EPMC5789541 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature