Synergistic effect of eugenol with Colistin against clinical isolated Colistin-resistant Escherichia coli strains.

ABSTRACT: Background:Bacterial infections have become more challenging to treat due to the emergence of multidrug-resistant pathogenic bacteria. Combined antibiotics prove to be a relatively effective method to control such resistant strains. This study aim to investigate synergistic activity of eugenol combined with colistin against a collection of clinical isolated Escherichia coli (E.coli) strains, and to evaluate potential interaction. Methods:Antimicrobial susceptibility, minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) of the bacteria were determined by disk diffusion assay, broth microdilution method and checkerboard assay, respectively. The mcr-1 mRNA expression was measured by Real-time PCR. To predict possible interactions between eugenol and MCR-

SUBMITTER: Wang YM 

PROVIDER: S-EPMC5789579 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature