Assessing runs of Homozygosity: a comparison of SNP Array and whole genome sequence low coverage data.

ABSTRACT:

Background

Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHs have been shedding light on human population history and deciphering the genetic basis of monogenic and complex traits and diseases. ROH studies have predominantly exploited SNP array data, but are gradually moving to whole genome sequence (WGS) data as it becomes available. WGS data, covering more genetic variability, can add value to ROH studies, but require additional considerations during analysis.

Results

Using SNP array and low coverage WGS data from 1885 individuals from 20 world populations, our aims were to compare ROH from the two datasets and to establish software cond

SUBMITTER: Ceballos FC 

PROVIDER: S-EPMC5789638 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature