Safety, tolerability and immunogenicity of an active anti-Aβ₄₀ vaccine (ABvac40) in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase I trial.

ABSTRACT:

Background

Immunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer's disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. We have developed the first active vaccine against the C-terminal end of Aβ₄₀, ABvac40, and assessed its safety and tolerability in a phase I clinical trial.

Methods

A randomised, double-blind, placebo-controlled, parallel-group, phase I study of ABvac40 was conducted with patients aged 50-85 years with mild to moderate AD. Participants were entered into three separate groups according to time of study entry and were randomly allocated to receive ABvac40 or placebo (overall ratio 2:1). The first group received two half-doses of ABva

SUBMITTER: Lacosta AM 

PROVIDER: S-EPMC5789644 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature