Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus.

ABSTRACT:

Background

Icariin (ICA), a major ingredient of Epimediumbrevicornum, has various pharmacological activities including central nervous system protective functions such as the improvement of learning and memory function in mice models of Alzheimer's disease. It has been reported that ICA can promote regeneration of peripheral nerve and functional recovery. The purpose of this study was to investigate the potentiating effect of ICA on the proliferation of rat hippocampal neural stem cells, and explore the possible mechanism involved.

Methods

Primary neural stem cells were prepared from the hippocampus of newly born SD rats, and cells were cultured in special stem cell culture medium. Neural stem cells were confirmed by immunofluorescence detection of nestin, NSE and GFAP expre

SUBMITTER: Fu X 

PROVIDER: S-EPMC5789743 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature