The hippocampal network model: A transdiagnostic metaconnectomic approach.

ABSTRACT:

Purpose

The hippocampus plays a central role in cognitive and affective processes and is commonly implicated in neurodegenerative diseases. Our study aimed to identify and describe a hippocampal network model (HNM) using trans-diagnostic MRI data from the BrainMap® database. We used meta-analysis to test the network degeneration hypothesis (NDH) (Seeley et al., 2009) by identifying structural and functional covariance in this hippocampal network.

Methods

To generate our network model, we used BrainMap's VBM database to perform a region-to-whole-brain (RtWB) meta-analysis of 269 VBM experiments from 165 published studies across a range of 38 psychiatric and neurological diseases reporting hippocampal gray matter density alterations. This step identified 11 significant gray ma

SUBMITTER: Kotkowski E 

PROVIDER: S-EPMC5789756 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature