Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer.

ABSTRACT: In mammals, the canonical somatic DNA methylation landscape is established upon specification of the embryo proper and subsequently disrupted within many cancer types. However, the underlying mechanisms that direct this genome-scale transformation remain elusive, with no clear model for its systematic acquisition or potential developmental utility. Here, we analysed global remethylation from the mouse preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions with substantial disruption of bimodal, CpG density-dependent methylation in the placental progenitor. The extraembryonic epigenome includes specific de novo methylation at hundreds of embryonically protected CpG island promoters, particularl

SUBMITTER: Smith ZD 

PROVIDER: S-EPMC5789792 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature