White matter hyperintensity shape and location feature analysis on brain MRI; proof of principle study in patients with diabetes.

ABSTRACT: Cerebral small vessel disease is a heterogeneous disease in which various underlying etiologies can lead to different types of white matter hyperintensities (WMH). WMH shape features might aid in distinguishing these different types. In this proof of principle study in patients with type 2 diabetes mellitus (T2DM), we present a novel approach to assess WMH using shape features. Our algorithm determines WMH volume and different WMH shape and location features on 3T MRI scans. These features were compared between patients with T2DM (n = 60) and a matched control group (n = 54). Although a more traditional marker (WMH volume) was not significantly different between groups (natural log transformed Beta (95% CI): 0.07 (-0.11↔0.24)), patients with T2DM showed a larger number of non-punctuate WMH

SUBMITTER: de Bresser J 

PROVIDER: S-EPMC5789823 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature