TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
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ABSTRACT:
SUBMITTER: Dutta Banik D
PROVIDER: S-EPMC5789955 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
Dutta Banik Debarghya D Martin Laura E LE Freichel Marc M Torregrossa Ann-Marie AM Medler Kathryn F KF
Proceedings of the National Academy of Sciences of the United States of America 20180108 4
Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. Transient receptor potential melastatin 5 (TRPM5), a sodium-selective TRP channel, functions as a common downstream component in sweet, bitter, and umami signaling pathways. In the absence of TRPM5, mice have a reduced, but not abolished, ability to detect stimuli, suggesting that a TRPM5-independent pathway also contributes to these signals. Here, we identif ...[more]
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