Ontology highlight
ABSTRACT:
SUBMITTER: McNally KE
PROVIDER: S-EPMC5790113 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nature cell biology 20170911 10
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval and recycling and, importantly, is biochemically and functionally distinct from the established retromer pathway. We have called this complex 'retriever'; it is a heterotrimer composed of DSCR3, C16orf62 and VPS ...[more]