Passively versus Actively Detected Malaria: Similar Genetic Diversity but Different Complexity of Infection.

ABSTRACT: The surveillance of malaria is generally undertaken on the assumption that samples passively collected at health facilities are comparable to or representative of the broader Plasmodium reservoir circulating in the community. Further characterization and comparability of the hidden asymptomatic parasite reservoir are needed to inform on the potential impact of sampling bias. This study explores the impact of sampling strategy on molecular surveillance by comparing the genetic make-up of Plasmodium falciparum and Plasmodium vivax isolates collected by passive versus active case detection. Sympatric isolates of P. falciparum and P. vivax were collected from a large community survey and ongoing clinical surveillance studies undertaken in the hypomesoendemic

SUBMITTER: Pava Z 

PROVIDER: S-EPMC5790166 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature