The Effects of Neoadjuvant Axitinib on Anthropometric Parameters in Patients With Locally Advanced Non-metastatic Renal Cell Carcinoma.

ABSTRACT:

Objective

To examine the effect that neoadjuvant axitinib for the treatment of localized renal cell carcinoma has on body compartment composition.

Materials and methods

The study was based on a single-institution, single-arm clinical trial that enrolled 24 patients with locally advanced non-metastatic biopsy-proven clear cell renal cell carcinoma. Patients received axitinib orally for up to 12 weeks. Computed tomography scans were completed before the start of treatment, after 7 weeks of treatment and at the completion of 12 weeks of treatment. Patients underwent nephrectomy after axitinib treatment. The primary outcome of the current study was change in body compartment composition. Secondary outcomes included development of new-onset sarcopenia and changes in body weight.<

SUBMITTER: Chery L 

PROVIDER: S-EPMC5790178 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature