Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions.

ABSTRACT:

Background

The presence of small dense low-density lipoprotein (LDL) is associated with obesity, type II diabetes, and an increased risk for cardiovascular disease. Apolipoprotein C-III (apoC-III) is involved in the formation of small dense LDL, but the exact mechanisms are still not well defined. ApoC-III is a glycosylated apolipoprotein, with 3 major glycoforms: apoC-III₀, apoC-III₁, and apoC-III₂ that contain 0, 1, or 2 molecules of sialic acid, respectively. In our previous work, we reported an association among apoC-III₀ and apoC-III₁, but not apoC-III₂ with fasting plasma triglyceride levels in obesity and type II diabetes.

Objective

The goal of this study was to determine the relationship between change

SUBMITTER: Mendoza S 

PROVIDER: S-EPMC5790205 | biostudies-literature | 2017 Jan - Feb

REPOSITORIES: biostudies-literature