The ratio between cerebral blood flow and Tmax predicts the quality of collaterals in acute ischemic stroke.

ABSTRACT:

Background

In acute ischemic stroke the status of collateral circulation is a critical factor in determining outcome. We propose a less invasive alternative to digital subtraction angiography for evaluating collaterals based on dynamic-susceptibility contrast magnetic resonance imaging.

Methods

Perfusion maps of Tmax and cerebral blood flow (CBF) were created for 35 patients with baseline occlusion of a major cerebral artery. Volumes of hypoperfusion were defined as having a Tmax delay of > 4 seconds (Tmax4s) and > 6 seconds (Tmax6s) and a CBF drop below 80% of healthy, contralateral tissue. For each patient a ratio between the volume of the CBF and the Tmax based perfusion deficit was calculated. Associations with collateral status and radiological outcome were assessed wit

SUBMITTER: Galinovic I 

PROVIDER: S-EPMC5790218 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature