Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study.

ABSTRACT:

Background

Traumatic brain injury (TBI) has been associated with dementia. The questions of whether the risk of dementia decreases over time after TBI, whether it is similar for different TBI types, and whether it is influenced by familial aggregation are not well studied.

Methods and findings

The cohort considered for inclusion comprised all individuals in Sweden aged ≥50 years on December 31, 2005 (n = 3,329,360). Diagnoses of dementia and TBI were tracked through nationwide databases from 1964 until December 31, 2012. In a first cohort, individuals diagnosed with TBI (n = 164,334) were matched with up to two controls. A second cohort consisted of subjects diagnosed with dementia during follow-up (n = 136,233) matched with up to two controls. A third cohort consisted of 46

SUBMITTER: Nordstrom A 

PROVIDER: S-EPMC5790223 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature