The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies.

ABSTRACT:

Background

The prognostic role of human epidermal growth factor receptor 2 (HER2) in ovarian cancer has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between HER2 expression and ovarian cancer prognosis.

Method

Observational studies published until July 2017 were searched in Pubmed, Embase, and Cochrane library databases. Hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, publication bias and sensitivity analyses were implemented under a standard manner. Estimates of overall survival (OS), progress-free survival (PFS) and disease-free survival (DFS) were weighted and pooled using Der Simonian-Laird random-effect model.

Result

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SUBMITTER: Luo H 

PROVIDER: S-EPMC5790275 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature