Molecular mechanisms of calcium signaling in the modulation of small intestinal ion transports and bicarbonate secretion.

ABSTRACT:

Background and purpose

Although Ca²⁺ signaling may stimulate small intestinal ion secretion, little is known about its critical role and the molecular mechanisms of Ca²⁺-mediated biological action.

Key results

Activation of muscarinic receptors by carbachol(CCh) stimulated mouse duodenal I_sc, which was significantly inhibited in Ca²⁺-free serosal solution and by several selective store-operated Ca²⁺ channels(SOC) blockers added to the serosal side of duodenal tissues. Furthermore, we found that CRAC/Orai channels may represent the molecular candidate of SOC in intestinal epithelium. CCh increased intracellular Ca²⁺ but not cAMP, and Ca²⁺ signaling mediated duodenal Cl^- and HCO

SUBMITTER: Yang X 

PROVIDER: S-EPMC5790495 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature