Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts.

ABSTRACT:

Purpose

There is a need for adjuvant/neo-adjuvant treatment strategies to prevent metastatic relapse in soft tissue sarcoma (STS). Tumor hypoxia is associated with a high-risk of metastasis and is potentially targetable. This study aimed to derive and validate a hypoxia mRNA signature for STS for future biomarker-driven trials of hypoxia targeted therapy.

Materials and methods

RNA sequencing was used to identify seed genes induced by hypoxia in seven STS cell lines. Primary tumors in a training cohort (French training) were clustered into two phenotypes by seed gene expression and a de novo hypoxia signature derived. Prognostic significance of the de novo signature was evaluated in the training and two independent validation (French validation and The Cancer Ge

SUBMITTER: Yang L 

PROVIDER: S-EPMC5790513 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature