Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis.

ABSTRACT: Bacteroides fragilis is the strict anaerobic bacteria most commonly found in human infections, and has a high mortality rate. Among other virulence factors, the remarkable ability to acquire resistance to a variety of antimicrobial agents and to tolerate nanomolar concentrations of oxygen explains in part their success in causing infection and colonizing the mucosa. Much attention has been given to genes related to multiple drug resistance derived from plasmids, integrons or transposon, but such genes are also detected in chromosomal systems, like the mar (multiple antibiotic resistance) locus, that confer resistance to a range of drugs. Regulators like MarR, that control expression of the locus mar, also regulate resistance to organic solvents, disinfectants and oxygen reactive species ar

SUBMITTER: Silva CMG 

PROVIDER: S-EPMC5790583 | biostudies-literature | 2018 Jan - Mar

REPOSITORIES: biostudies-literature