Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections.

ABSTRACT: Current immunosuppression regimens in organ transplantation primarily inhibit T cells. However, T cells are also critical in protective immunity, especially in immune-compromised patients. In this study, we examined the association of T cell dysfunction, as marked by expression of T cell exhaustion molecules, and posttransplant infections in a cohort of liver transplant patients. We focused on Programmed Death 1 (PD-1) and T cell Ig- and mucin-domain molecule 3 (Tim-3), which are potent co-inhibitory receptors, and their persistent expression often leads to T cell dysfunction and compromised protective immunity. We found that patients with the highest expression of PD-1 +Tim-3+ T cells in the memory compartment before transplantation had increased incidence of infections after liver transp

SUBMITTER: Mysore KR 

PROVIDER: S-EPMC5790618 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature