Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis (TB) is the leading cause of death by an infectious disease, and global TB control efforts are increasingly threatened by drug resistance in Mycobacterium tuberculosis. Unlike most bacteria, where lateral gene transfer is an important mechanism of resistance acquisition, resistant M. tuberculosis arises solely by de novo chromosomal mutation. Using whole-genome sequencing data from two natural populations of M. tuberculosis, we characterized the population genetics of known drug resistance loci using measures of diversity, population differentiation, and convergent evolution. We found resistant subpopulations to be less diverse than susceptible subpopulations, consistent with ongoing transmission of resistant M. tuberculosis. A subset of resi

SUBMITTER: Mortimer TD 

PROVIDER: S-EPMC5790871 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature